The Popo Agie River Basin is located on the eastern slope of the Wind River Mountains near Lander, Wyoming. The North Fork of Popo Agie can be reached by driving north out of Lander on State highway 287. The North Fork forms the boundary of the Wind River Indian Reservation. There are numerous 4WD roads heading west before you reach the Wind River Reservation that parallel the North Fork. Most of the lower reaches of the North Fork are privately owned and the upper reaches are only accessible through the Wind River Indian Reservation driving southwest out of Fort Washakie on Moccasin Lake Road. All travelers must stay ON this road and turn south on Forest Road 329. Any deviations will be ticketed by the Tribal Police. The Middle Fork of the Popo Agie can be reached by driving southwest out of Lander on State Highway 131. This road broadly parallels the river. To reach the headwaters and upper reaches of the middle fork, park at the Middle Fork Trailhead at the end of State Highway 131. This trail closely follows the Middle Fork of the Popo Agie for the next 14 miles - all accessible by foot or horseback. The Little Popo Agie can be accessed by taking the "Loop Road," State Highway 131, southwest out of Lander. At the base of the mountain the road turns into a well maintained dirt road labeled Forest Road 300. This road is kept open only as long as it is without heavy snow pack - generally closed from Dec 1 to May 1.